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XLVII.h

XLVII - Mediastinal involvement

Pneumomediastinum

Last update 19/02/2021

Of note, peritracheal and/or submucosal air/gas may obstruct the upper/central airway causing asphyxia. See also under Vf. Pneumomediastinum may cause mediastinal shift or compression with consequent acute respiratory failure (PMID 19748792). Pneumomediastinum can also be observed as a complication of drug-induced ILD, pulmonary fibrosis, or ARDS, either spontaneously or as a complication of barotrauma (e.g. with pulmonary function testing or mechanical ventilation).

Causative drugs

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases