The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

VIII.a

Angioedema (may cause UAO, asphyxia and death)

Publications

Goksel O, Goksel T, Cok G, Karakus H, Bacakoglu F, Goker E, Uslu R, Erdinc M

Hypersensitivity to chemotherapeutics: a cross sectional study with 35 desensitisations.

International journal of clinical oncology. 2015;20(2):395-404

Shanholtz C

Acute life-threatening toxicity of cancer treatment.

Critical care clinics. 2001;17(3):483-502

Tsavaris NB, Kosmas C

Risk of severe acute hypersensitivity reactions after rapid paclitaxel infusion of less than 1-h duration.

Cancer chemotherapy and pharmacology. 1998;42(6):509-11

Alkins SA, Byrd JC, Morgan SK, Ward FT, Weiss RB

Anaphylactoid reactions to methotrexate.

Cancer. 1996;77(10):2123-6

Chang SM, Fryberger S, Crouse V, Tilford D, Prados MD

Carboplatin hypersensitivity in children. A report of five patients with brain tumors.

Cancer. 1995;75(5):1171-5

Kellie SJ, Crist WM, Pui CH, Crone ME, Fairclough DL, Rodman JH, Rivera GK

Hypersensitivity reactions to epipodophyllotoxins in children with acute lymphoblastic leukemia.

Cancer. 1991;67(4):1070-5