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The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

III.a

Alveolar hemorrhage (AH), diffuse AH (DAH)

Publications

Martín-Macho González M, López Hormiga D, Cívico Martín E

Pulmonary complications for drug consumption: Diffuse alveolar hemorrhage.

Medicina intensiva. 2021;45(9):569

Yamanoglu A, Cakmak S, Celebi Yamanoglu NG, Sogut O

A new side effect of synthetic cannabinoid use by the bucket (waterpipe) method: Acute respiratory distress syndrome (ARDS).

Turkish journal of emergency medicine. 2018;18(1):42-44

de Prost N, Parrot A, Cuquemelle E, Picard C, Antoine M, Fleury-Feith J, Mayaud C, Boffa JJ, Fartoukh M, Cadranel J

Diffuse alveolar hemorrhage in immunocompetent patients: etiologies and prognosis revisited.

Respiratory medicine. 2012;106(7):1021-32

Todorović MS, Mitrović S, Aleksandrić B, Mladjenović N, Matejić S

Association of pulmonary histopathological findings with toxicological findings in forensic autopsies of illicit drug users.

Vojnosanitetski pregled. 2011;68(8):639-42

Grassin F, André M, Rallec B, Combes E, Vinsonneau U, Paleiron N

[Fatal alveolar haemorrhage following a "bang" of cannabis].

Revue des maladies respiratoires. 2011;28(7):919-23

Porter R, O'Reilly H

Pulmonary hemorrhage: a rare complication of opioid overdose.

Pediatric emergency care. 2011;27(8):742-4

Restrepo CS, Artunduaga M, Carrillo JA, Rivera AL, Ojeda P, Martinez-Jimenez S, Manzano AC, Rossi SE

Silicone pulmonary embolism: report of 10 cases and review of the literature.

Journal of computer assisted tomography. 2009;33(2):233-7