The Drug-Induced Respiratory Disease Website and App

E-cigarette - E-vaporizers - ENDS - Vaping - Dabbing

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

II.e

ARDS - Acute lung injury

Mechanical ventilation requaired in about a third. ECMO needed in some. Fatality rate 2%.

Publications

Hayes D, Board A, Calfee C, Ellington S, Pollack LA, Kathuria H, Eakin MN, Weissman DN, Callahan SJ, Esper AM, Crotty Alexander LE, Sharma NS, Meyer NJ, Smith LS, Novosad S, Evans ME, Goodman AB, Click ES, Robinson RT, Ewart G, Twentyman E

"Pulmonary and Critical Care Considerations for E-cigarette, or Vaping, Product Use-Associated Lung Injury (EVALI)".

Chest 2022 Mar 04;; — 2022 Mar 04

Marlière C, De Greef J, Gohy S, Hoton D, Wallemacq P, Jacquet LM, Belkhir L

Fatal e-cigarette or vaping associated lung injury (EVALI): a first case report in Europe.

The European respiratory journal 2020 Mar 26;; — 2020 Mar 26

Cherian SV, Kumar A, Estrada-Y-Martin RM

E-cigarette or Vaping- product associated lung injury: A review.

The American journal of medicine 2020 Mar 13;; — 2020 Mar 13

Lu MA, Jabre NA, Mogayzel PJ

Vaping-Related Lung Injury in an Adolescent.

American journal of respiratory and critical care medicine 2020 Jan 06;; — 2020 Jan 06

Hartnett KP, Kite-Powell A, Patel MT, Haag BL, Sheppard MJ, Dias TP, King BA, Melstrom PC, Ritchey MD, Stein Z, Idaikkadar N, Vivolo-Kantor AM, Rose DA, Briss PA, Layden JE, Rodgers L, Adjemian J

Syndromic Surveillance for E-Cigarette, or Vaping, Product Use-Associated Lung Injury.

The New England journal of medicine 2020 Feb 20;382 — 2020 Feb 20 — 766-772

Blount BC, Karwowski MP, Shields PG, Morel-Espinosa M, Valentin-Blasini L, Gardner M, Braselton M, Brosius CR, Caron KT, Chambers D, Corstvet J, Cowan E, De Jesús VR, Espinosa P, Fernandez C, Holder C, Kuklenyik Z, Kusovschi JD, Newman C, Reis GB, Rees J,

Vitamin E Acetate in Bronchoalveolar-Lavage Fluid Associated with EVALI.

The New England journal of medicine 2019 Dec 20;; — 2019 Dec 20

Sakla NM, Gattu R, Singh G, Sadler M

Vaping-associated acute respiratory distress syndrome.

Emergency radiology 2019 Dec 09;; — 2019 Dec 09

Butt YM, Smith ML, Tazelaar HD, Vaszar LT, Swanson KL, Cecchini MJ, Boland JM, Bois MC, Boyum JH, Froemming AT, Khoor A, Mira-Avendano I, Patel A, Larsen BT

Pathology of Vaping-Associated Lung Injury.

The New England journal of medicine 2019 Oct 02;; — 2019 Oct 02

Triantafyllou GA, Tiberio PJ, Zou RH, Lamberty PE, Lynch MJ, Kreit JW, Gladwin MT, Morris A, Chiarchiaro J

Vaping-Associated Acute Lung Injury: A Case Series.

American journal of respiratory and critical care medicine 2019 Oct 01;; — 2019 Oct 01

Layden JE, Ghinai I, Pray I, Kimball A, Layer M, Tenforde M, Navon L, Hoots B, Salvatore PP, Elderbrook M, Haupt T, Kanne J, Patel MT, Saathoff-Huber L, King BA, Schier JG, Mikosz CA, Meiman J

Pulmonary Illness Related to E-Cigarette Use in Illinois and Wisconsin - Preliminary Report.

The New England journal of medicine 2019 Sep 06;; — 2019 Sep 06

Sommerfeld CG, Weiner DJ, Nowalk A, Larkin A

Hypersensitivity Pneumonitis and Acute Respiratory Distress Syndrome From E-Cigarette Use.

Pediatrics 2018 06;141; — 2018 06