The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XVI.ab

Imaging: Cavitating/cavitary lung nodule, mass or nodules (see also Iq, XIs, XIIi, XVIaa and XVIIp)

Publications

Giroux Leprieur E, Dumenil C, Labrune S, Giraud V, Chinet T

Bilateral pneumothorax complicating cystic metastases of bronchial squamous cell carcinoma under erlotinib.

Tumori. 2013;99(2):e77-9

Thalinger AR, Rosenthal SN, Borg S, Arseneau JC

Cavitation of pulmonary metastases as a response to chemotherapy.

Cancer. 1980;46(6):1329-32

Kryger-Baggesen N

Spontaneous pneumothorax following regression of pulmonary metastases.

The European respiratory journal. 1990;3(4):485-6