The Drug-Induced Respiratory Disease Website and App

Corticosteroids, systemic (oral, parenteral)

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLVIII.a

Diaphragm/inspiratory muscle weakness/paralysis (w/wo ARF)

Publications

Teagarden CM, Picardo CW

Betamethasone-induced hypokalemic periodic paralysis in pregnancy.

Obstetrics and gynecology 2011 Feb;117;433-5 — 2011 Feb — 433-5

Schweickert WD, Hall J

ICU-acquired weakness.

Chest 2007 May;131;1541-9 — 2007 May — 1541-9

Deem S

Intensive-care-unit-acquired muscle weakness.

Respiratory care 2006 Sep;51;1042-52; discussion 1052-3 — 2006 Sep — 1042-52; discussion 1052-3

Nava S, Fracchia C, Callegari G, Ambrosino N, Barbarito N, Felicetti G

Weakness of respiratory and skeletal muscles after a short course of steroids in patients with acute lung rejection.

The European respiratory journal 2002 Aug;20;497-9 — 2002 Aug — 497-9

Akkoca O, Mungan D, Karabiyikoglu G, Misirligil Z

Inhaled and systemic corticosteroid therapies: Do they contribute to inspiratory muscle weakness in asthma?

Respiration; international review of thoracic diseases 1999;66;332-7 — 1999 — 332-7

Decramer M, de Bock V, Dom R

Functional and histologic picture of steroid-induced myopathy in chronic obstructive pulmonary disease.

American journal of respiratory and critical care medicine 1996 Jun;153;1958-64 — 1996 Jun — 1958-64

Malandrini A, Scarpini C, Fabrizi GM, Manneschi L, Rosi R, Parrotta E, Guazzi GC

Mitochondrial changes in steroid myopathy with respiratory failure and rapid fatal course: report of a case.

European neurology 1995;35;182-3 — 1995 — 182-3

Bowyer SL, LaMothe MP, Hollister JR

Steroid myopathy: incidence and detection in a population with asthma.

The Journal of allergy and clinical immunology 1985 Aug;76;234-42 — 1985 Aug — 234-42

Williams TJ, O'Hehir RE, Czarny D, Horne M, Bowes G

Acute myopathy in severe acute asthma treated with intravenously administered corticosteroids.

The American review of respiratory disease 1988 Feb;137;460-3 — 1988 Feb — 460-3