The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Diaphragm/inspiratory muscle weakness/paralysis (w/wo ARF)
Publications
Betamethasone-induced hypokalemic periodic paralysis in pregnancy.
Obstetrics and gynecology. 2011;117(2 Pt 2):433-435
ICU-acquired weakness.
Chest. 2007;131(5):1541-9
Intensive-care-unit-acquired muscle weakness.
Respiratory care. 2006;51(9):1042-52; discussion 1052-3
Weakness of respiratory and skeletal muscles after a short course of steroids in patients with acute lung rejection.
The European respiratory journal. 2002;20(2):497-9
Inhaled and systemic corticosteroid therapies: Do they contribute to inspiratory muscle weakness in asthma?
Respiration; international review of thoracic diseases. 1999;66(4):332-7
Functional and histologic picture of steroid-induced myopathy in chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine. 1996;153(6 Pt 1):1958-64
Mitochondrial changes in steroid myopathy with respiratory failure and rapid fatal course: report of a case.
European neurology. 1995;35(3):182-3
Steroid myopathy: incidence and detection in a population with asthma.
The Journal of allergy and clinical immunology. 1985;76(2 Pt 1):234-42
Acute myopathy in severe acute asthma treated with intravenously administered corticosteroids.
The American review of respiratory disease. 1988;137(2):460-3