The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

X.u

Vasculitis, pulmonary (w/wo AH), extrapulmonary, systemic: ANCA-positive

Clinical and laboratory features may mimic those of ANCA-related polyangiitis and granulomatosis. The 2000s onwards, levamisole-tainted cocaine accounts for most cocaine-related ANCA disease

Publications

Kötter I, Reinhold-Keller E

[Vasculitis mimics].

Zeitschrift fur Rheumatologie 2019 Feb;78;24-30 — 2019 Feb — 24-30

Muñoz-Vahos CH, Herrera-Uribe S, Arbeláez-Cortés Á, Jaramillo-Arroyave D, González-Naranjo LA, Vásquez-Duque G, Restrepo-Escobar M, Correa-Londoño LA, Arias-Restrepo LF, Vanegas-García AL

Clinical Profile of Levamisole-Adulterated Cocaine-Induced Vasculitis/Vasculopathy: A 30-Case Series.

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases 2019 Apr;25;e16-e26 — 2019 Apr — e16-e26

Subesinghe S, van Leuven S, Yalakki L, Sangle S, D'Cruz D

Cocaine and ANCA associated vasculitis-like syndromes - A case series.

Autoimmunity reviews 2018 Jan;17;73-77 — 2018 Jan — 73-77

Jiménez-Gallo D, Albarrán-Planelles C, Linares-Barrios M, Rodríguez-Hernández C, Martínez-Rodríguez A, García-Moreno E, Bravo-Monge R

Pyoderma gangrenosum and Wegener granulomatosis-like syndrome induced by cocaine.

Clinical and experimental dermatology 2013 Dec;38;878-82 — 2013 Dec — 878-82

Strazzula L, Brown KK, Brieva JC, Camp BJ, Frankel HC, Kissin E, Mahlberg MJ, Mina MA, Pomeranz MK, Brownell I, Kroshinsky D

Levamisole toxicity mimicking autoimmune disease.

Journal of the American Academy of Dermatology 2013 Dec;69;954-9 — 2013 Dec — 954-9

Sánchez-Cruz A, Marrero S, Betancourt J, Andino M, Lopez A, Gutierrez-Nuñez J

Cocaine induced vasculitis: have we found a culprit?

Case reports in rheumatology 2012;2012;982361 — 2012 — 982361

McGrath MM, Isakova T, Rennke HG, Mottola AM, Laliberte KA, Niles JL

Contaminated cocaine and antineutrophil cytoplasmic antibody-associated disease.

Clinical journal of the American Society of Nephrology : CJASN 2011 Dec;6;2799-805 — 2011 Dec — 2799-805

Specks U

The growing complexity of the pathology associated with cocaine use.

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases 2011 Jun;17;167-8 — 2011 Jun — 167-8

Neynaber S, Mistry-Burchardi N, Rust C, Samtleben W, Burgdorf WH, Seitz MA, Messer G, Wollenberg A

PR3-ANCA-positive necrotizing multi-organ vasculitis following cocaine abuse.

Acta dermato-venereologica 2008;88;594-6 — 2008 — 594-6

Rachapalli SM, Kiely PD

Cocaine-induced midline destructive lesions mimicking ENT-limited Wegener's granulomatosis.

Scandinavian journal of rheumatology 2008 Nov-Dec;37;477-80 — 2008 Nov-Dec — 477-80

Friedman DR, Wolfsthal SD

Cocaine-induced pseudovasculitis.

Mayo Clinic proceedings 2005 May;80;671-3 — 2005 May — 671-3