The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.x

Rapidly progressive ILD/pulmonary fibrosis (Hamman-Rich syndrome)

Publications

Zorzi AP, Yang CL, Dell S, Nathan PC

Bleomycin-associated Lung Toxicity in Childhood Cancer Survivors.

Journal of pediatric hematology/oncology 2015 Nov;37;e447-52 — 2015 Nov — e447-52

Batra S, Vaid AK, Bhargava R, Gupta S

Lungs on fire.

BMJ case reports 2013 Jun 27;2013; — 2013 Jun 27

Keijzer A, Kuenen B

Fatal pulmonary toxicity in testis cancer with bleomycin-containing chemotherapy.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007 Aug 10;25;3543-4 — 2007 Aug 10 — 3543-4