The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Respiratory failure from ventilatory depression (due to neuromuscular blockade/paralysis)
Publications
Respiratory failure in confirmed synthetic cannabinoid overdose.
Clinical toxicology (Philadelphia, Pa.) 2021 Sep 09;;1-3 — 2021 Sep 09 — 1-3
Synthetic cannabinoid induced acute respiratory depression: Case series and literature review.
Respiratory medicine case reports 2017;22;137-141 — 2017 — 137-141
Clinical toxicity following analytically confirmed use of the synthetic cannabinoid receptor agonist MDMB-CHMICA. A report from the Identification Of Novel psychoActive substances (IONA) study.
Clinical toxicology (Philadelphia, Pa.) 2016 Sep;54;638-43 — 2016 Sep — 638-43
Synthetic cannabis and respiratory depression.
Journal of child and adolescent psychopharmacology 2012 Dec;22;459-62 — 2012 Dec — 459-62