The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
BAL: Oil red O-stainable material in BAL macrophages othen than exogenous lipids
Critical discussion at PMID 31985892
Publications
Harry-Hernandez S, Thiboutot J, Wahidi MM, Giovacchini CX, De Cardenas J, Meldrum C, Los JG, Illei PB, Shojaee S, Eissenberg T, DiBardino D, Giannini H, Maldonado F, Roller L, Yarmus LB, Kapp CM
Bronchoalveolar Lavage (BAL) and Pathologic Assessment of Electronic Cigarette or Vaping Product Use-associated Lung Injury (EVALI): The EVALI-BAL Study, A Multicenter Cohort.
Journal of bronchology & interventional pulmonology. 2023;30(2):144-154
Rapid Resolution of Severe Vaping-induced Acute Lipoid Pneumonia after Corticosteroid Treatment.
American journal of respiratory and critical care medicine. 2020;202(2):e32-e33
Pulmonary Lipid-Laden Macrophages and Vaping.
The New England journal of medicine. 2019;381(15):1488-1489
Layden JE, Ghinai I, Pray I, Kimball A, Layer M, Tenforde MW, Navon L, Hoots B, Salvatore PP, Elderbrook M, Haupt T, Kanne J, Patel MT, Saathoff-Huber L, King BA, Schier JG, Mikosz CA, Meiman J
Pulmonary Illness Related to E-Cigarette Use in Illinois and Wisconsin - Final Report.
The New England journal of medicine. 2020;382(10):903-916
An unexpected consequence of electronic cigarette use.
Chest. 2012;141(4):1110-1113