The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.e

Organizing pneumonia pattern (an area or areas of consolidation on imaging)

Publications

Maldonado F, Daniels CE, Hoffman EA, Yi ES, Ryu JH

Focal organizing pneumonia on surgical lung biopsy: causes, clinicoradiologic features, and outcomes.

Chest 2007 Nov;132;1579-83 — 2007 Nov — 1579-83

Santrach PJ, Askin FB, Wells RJ, Azizkhan RG, Merten DF

Nodular form of bleomycin-related pulmonary injury in patients with osteogenic sarcoma.

Cancer 1989 Aug 15;64;806-11 — 1989 Aug 15 — 806-11

Dineen MK, Englander LS, Huben RP

Bleomycin-induced nodular pulmonary fibrosis masquerading as metastatic testicular cancer.

The Journal of urology 1986 Aug;136;473-5 — 1986 Aug — 473-5