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The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

VI.g

Foreign body pulmonary vasculopathy (Excipient lung disease)

Publications

Pena E, Dennie C, Franquet T, Milroy C

Nonthrombotic pulmonary embolism: a radiological perspective.

Seminars in ultrasound, CT, and MR. 2012;33(6):522-34

Griffith CC, Raval JS, Nichols L

Intravascular Talcosis due to Intravenous Drug Use Is an Underrecognized Cause of Pulmonary Hypertension.

Pulmonary medicine. 2012;2012:617531

Milroy CM, Parai JL

The histopathology of drugs of abuse.

Histopathology. 2011;59(4):579-93

Passarino G, Ciccone G, Siragusa R, Tappero P, Mollo F

Histopathological findings in 851 autopsies of drug addicts, with toxicologic and virologic correlations.

The American journal of forensic medicine and pathology. 2005;26(2):106-16

WENDT VE, PURO HE, SHAPIRO J, MATHEWS W, WOLF PL

ANGIOTHROMBOTIC PULMONARY HYPERTENSION IN ADDICTS. "BLUE VELVET" ADDICTION.

JAMA. 1964;188:755-7

Lemoine R, Dusmet M

Images in clinical medicine. Pulmonary granulomas in an intravenous drug user.

The New England journal of medicine. 2000;343(18):1312

Waller BF, Brownlee WJ, Roberts WC

Self-induced pulmonary granulomatosis. A consequence of intravenous injection of drugs intended for oral use.

Chest. 1980;78(1):90-4

Farber H, Glauser FL

The effect of oral hydralazine on the pulmonary hemodynamics of patients with pulmonary foreign body granulomatosis.

Chest. 1982;82(6):708-12

Zeltner TB, Nussbaumer U, Rudin O, Zimmermann A

Unusual pulmonary vascular lesions after intravenous injections of microcrystalline cellulose. A complication of pentazocine tablet abuse.

Virchows Archiv. A, Pathological anatomy and histology. 1982;395(2):207-16

Bainborough AR, Jericho KW

Cor pulmonale secondary to talc granulomata in the lungs of a drug addict.

Canadian Medical Association journal. 1970;103(12):1297-8

Hopkins GB

Pulmonary angiothrombotic granulomatosis in drug offenders.

JAMA. 1972;221(8):909-11

Genereux GP, Emson HE

Talc granulomatosis and angiothrombotic pulmonary hypertension in drug addicts.

Journal of the Canadian Association of Radiologists. 1974;25(2):87-93

Røger M, Rognum TO, Ingum J, Welle-Strand G

[Intravenous abuse of crushed tablets. A case with fatal outcome].

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke. 1990;110(16):2080-1