The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLII.a

Alveolar hemorrhage (AH), diffuse AH (DAH)

Publications

Papaioannou V, Terzi I, Dragoumanis C, Pneumatikos I

Negative-pressure acute tracheobronchial hemorrhage and pulmonary edema.

Journal of anesthesia 2009;23;417-20 — 2009 — 417-20

Dolinski SY, MacGregor DA, Scuderi PE

Pulmonary hemorrhage associated with negative-pressure pulmonary edema.

Anesthesiology 2000 Sep;93;888-90 — 2000 Sep — 888-90