The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.b

Pneumonitis (ILD), acute and/or severe (may cause ARDS)

Publications

Ochoa R, Bejarano PA, Glück S, Montero AJ

Pneumonitis and pulmonary fibrosis in a patient receiving adjuvant docetaxel and cyclophosphamide for stage 3 breast cancer: a case report and literature review.

Journal of medical case reports 2012 Nov 30;6;413 — 2012 Nov 30 — 413

Muneoka K, Shirai Y, Sasaki M, Wakai T, Sakata J, Hatakeyama K

Interstitial pneumonia arising in a patient treated with oxaliplatin, 5-fluorouracil, and, leucovorin (FOLFOX).

International journal of clinical oncology 2009 Oct;14;457-9 — 2009 Oct — 457-9

Alessandrino EP, Bernasconi P, Colombo A, Caldera D, Martinelli G, Vitulo P, Malcovati L, Nascimbene C, Varettoni M, Volpini E, Klersy C, Bernasconi C

Pulmonary toxicity following carmustine-based preparative regimens and autologous peripheral blood progenitor cell transplantation in hematological malignancies.

Bone marrow transplantation 2000 Feb;25;309-13 — 2000 Feb — 309-13

Kornek GV, Haider K, Kwasny W, Hejna M, Raderer M, Meghdadi S, Burger D, Schneeweiss B, Depisch D, Scheithauer W

Effective treatment of advanced breast cancer with vinorelbine, mitomycin C plus human granulocyte colony-stimulating factor.

British journal of cancer 1996 Nov;74;1668-73 — 1996 Nov — 1668-73