The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Path: Acute/subacute bronchiolitis (see also IVc, IVi)
Publications
A 43-Year-Old Brazilian Man with Acute Impairment of Lung Function and Pulmonary Nodules with Features of Electronic Cigarette or Vaping Product Use-Associated Lung Injury (EVALI).
The American journal of case reports 2023 May 03;24;e939365 — 2023 May 03 — e939365
Fatal e-cigarette or vaping associated lung injury (EVALI): a first case report in Europe.
The European respiratory journal 2020 Mar 26;; — 2020 Mar 26
Secondhand smoke from electronic cigarette resulting in hypersensitivity pneumonitis.
BMJ case reports 2020 Mar 22;13; — 2020 Mar 22
Persistent Severe Fixed Airways Obstruction in a High-Dosing E-cigarette User.
Journal of general internal medicine 2019 Nov 08;; — 2019 Nov 08
Butt YM, Smith ML, Tazelaar HD, Vaszar LT, Swanson KL, Cecchini MJ, Boland JM, Bois MC, Boyum JH, Froemming AT, Khoor A, Mira-Avendano I, Patel A, Larsen BT
Pathology of Vaping-Associated Lung Injury.
The New England journal of medicine 2019 Oct 02;; — 2019 Oct 02
Flavorings in electronic cigarettes: an unrecognized respiratory health hazard?
JAMA 2014 Dec 17;312;2493-4 — 2014 Dec 17 — 2493-4