The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

X.g

Hypersensitivity reaction (may manifest with fever and/or skin, throat or airway involvement)

Publications

Goksel O, Goksel T, Cok G, Karakus H, Bacakoglu F, Goker E, Uslu R, Erdinc M

Hypersensitivity to chemotherapeutics: a cross sectional study with 35 desensitisations.

International journal of clinical oncology. 2015;20(2):395-404

Cortijo-Cascajares S, Jiménez-Cerezo MJ, Herreros de Tejada A

Review of hypersensitivity reactions to antineoplastic agents.

Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria. 2012;36(3):148-58

Lee C, Gianos M, Klaustermeyer WB

Diagnosis and management of hypersensitivity reactions related to common cancer chemotherapy agents.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology. 2009;102(3):179-87; quiz 187-9, 222

Shepherd GM

Hypersensitivity reactions to chemotherapeutic drugs.

Clinical reviews in allergy & immunology. 2003;24(3):253-62