The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

X.m

Vascultis (pulmonary, extrathoracic or systemic)-ANCA status unknown or negative)

Specifically called cocaine-induced pseudovasculitis (CIP)

Publications

Sánchez-Cruz A, Marrero S, Betancourt J, Andino M, Lopez A, Gutierrez-Nuñez J

Cocaine induced vasculitis: have we found a culprit?

Case reports in rheumatology. 2012;2012:982361

Espinoza LR, Perez Alamino R

Cocaine-induced vasculitis: clinical and immunological spectrum.

Current rheumatology reports. 2012;14(6):532-8

Pearson T, Bremmer M, Cohen J, Driscoll M

Vasculopathy related to cocaine adulterated with levamisole: A review of the literature.

Dermatology online journal. 2012;18(7):1

Morris GW Jr, Mason BC, Harris Sprunger R, Hake Harris H, White LA, Patterson DA

Levamisole-adulterated cocaine: a case series.

Journal of the American Board of Family Medicine : JABFM. 2012;25(4):531-5

Lee KC, Ladizinski B, Federman DG

Complications associated with use of levamisole-contaminated cocaine: an emerging public health challenge.

Mayo Clinic proceedings. 2012;87(6):581-6