The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.b

Pneumonitis (interstitial lung disease/ILD)

Publications

Guilleminault L, Sigmann MH, Paganin F

A good night for a bad day.

Thorax. 2015;70(6):604, 607

Mançano A, Marchiori E, Zanetti G, Escuissato DL, Duarte BC, Apolinário Lde A

Pulmonary complications of crack cocaine use: high-resolution computed tomography of the chest.

Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia. 2008;34(5):323-7

Laposata EA, Mayo GL

A review of pulmonary pathology and mechanisms associated with inhalation of freebase cocaine ("crack").

The American journal of forensic medicine and pathology. 1993;14(1):1-9

O'Donnell AE, Mappin FG, Sebo TJ, Tazelaar H

Interstitial pneumonitis associated with "crack" cocaine abuse.

Chest. 1991;100(4):1155-7