The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Path: Pulmonary veno-occlusive disease (PVOD)
Publications
In situ thrombosis of small pulmonary arteries in pulmonary hypertension developing after chemotherapy for malignancy.
Pulmonary medicine. 2015;2015:230846
Ranchoux B, Günther S, Quarck R, Chaumais MC, Dorfmüller P, Antigny F, Dumas SJ, Raymond N, Lau E, Savale L, Jaïs X, Sitbon O, Simonneau G, Stenmark K, Cohen-Kaminsky S, Humbert M, Montani D, Perros F
Chemotherapy-induced pulmonary hypertension: role of alkylating agents.
The American journal of pathology. 2015;185(2):356-71
Miyata D, Fukushima T, Matsunaga M, Saito N, Kato Y, Takahashi-Igari M, Horigome H, Sumazaki R, Yamaki S, Matsui A
Fatal pulmonary veno-occlusive disease after chemotherapy for Burkitt's lymphoma.
Pediatrics international : official journal of the Japan Pediatric Society. 2011;53(3):403-5
Pulmonary veno-occlusive disease after chemotherapy.
Thorax. 1985;40(11):874-5
Fatal pulmonary arterial occlusive vascular disease following chemotherapy in a 9-month-old infant.
Human pathology. 1991;22(12):1295-8