The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

VII.h

Pneumomediastinum

Publications

Barras M, Uhlmann M

Spontaneous Pneumomediastinum and Bilateral Pneumothoraces in a Patient with Bleomycin-Induced Pneumonitis.

European journal of case reports in internal medicine. 2017;4(10):000727

Jennane S, Haidouri S, Zine Filali K, Ahchouch S, Mahtat EM, Doghmi K, Mikdame M

[Fatal bleomycin induced pneumomediastinum and bilateral pneumothorax].

Revue de pneumologie clinique. 2017;73(3):153-156

Sikdar T, MacVicar D, Husband JE

Pneumomediastinum complicating bleomycin related lung damage.

The British journal of radiology. 1998;71(851):1202-4