The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Path: Pneumocyte atypia (reactive epithelial cells) (a.k.a. the "Napoleon Hat" sign)
Publications
"Napoleon Hat" Sign: A Distinctive Cytologic Clue to Reactive Pneumocytes.
Archives of pathology & laboratory medicine 2020 Jan 23;; — 2020 Jan 23
Pneumonitis and pulmonary fibrosis in a patient receiving adjuvant docetaxel and cyclophosphamide for stage 3 breast cancer: a case report and literature review.
Journal of medical case reports 2012 Nov 30;6;413 — 2012 Nov 30 — 413
Drug-induced lung disease: a pragmatic classification incorporating HRCT appearances.
Seminars in respiratory and critical care medicine 2003 Aug;24;445-54 — 2003 Aug — 445-54
Epithelial atypias with chemotherapy in 100 acute childhood leukemias.
Cancer 1955 Jan-Feb;8;179-86 — 1955 Jan-Feb — 179-86