The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XV.i

Path: Pneumocyte atypia (reactive epithelial cells) (a.k.a. the "Napoleon Hat" sign)

Publications

Rekhtman N

"Napoleon Hat" Sign: A Distinctive Cytologic Clue to Reactive Pneumocytes.

Archives of pathology & laboratory medicine. 2020;144(4):443-445

Ochoa R, Bejarano PA, Glück S, Montero AJ

Pneumonitis and pulmonary fibrosis in a patient receiving adjuvant docetaxel and cyclophosphamide for stage 3 breast cancer: a case report and literature review.

Journal of medical case reports. 2012;6:413

Myers JL, Limper AH, Swensen SJ

Drug-induced lung disease: a pragmatic classification incorporating HRCT appearances.

Seminars in respiratory and critical care medicine. 2003;24(4):445-54

WESTON JT, GUIN GH

Epithelial atypias with chemotherapy in 100 acute childhood leukemias.

Cancer. 1955;8(1):179-86