The Drug-Induced Respiratory Disease Website and App

Corticosteroids, systemic (oral, parenteral)

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XVII.a

Respiratory tract infection incl. pneumonia

Publications

Yao TC, Wang JY, Chang SM, Chang YC, Tsai YF, Wu AC, Huang JL, Tsai HJ

Association of Oral Corticosteroid Bursts With Severe Adverse Events in Children.

JAMA pediatrics. 2021;175(7):723-729

Price DB, Trudo F, Voorham J, Xu X, Kerkhof M, Ling Zhi Jie J, Tran TN

Adverse outcomes from initiation of systemic corticosteroids for asthma: long-term observational study.

Journal of asthma and allergy. 2018;11:193-204

Suissa S, Patenaude V, Lapi F, Ernst P

Inhaled corticosteroids in COPD and the risk of serious pneumonia.

Thorax. 2013;68(11):1029-36

McKeever T, Harrison TW, Hubbard R, Shaw D

Inhaled corticosteroids and the risk of pneumonia in people with asthma: a case-control study.

Chest. 2013;144(6):1788-1794