The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

L.t

Cavitation/necrosis of lung tumor or metastases

Publications

Phernambucq EC, Hartemink KJ, Smit EF, Paul MA, Postmus PE, Comans EF, Senan S

Tumor cavitation in patients with stage III non-small-cell lung cancer undergoing concurrent chemoradiotherapy: incidence and outcomes.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2012 Aug;7;1271-5 — 2012 Aug — 1271-5

Thalinger AR, Rosenthal SN, Borg S, Arseneau JC

Cavitation of pulmonary metastases as a response to chemotherapy.

Cancer 1980 Sep 15;46;1329-32 — 1980 Sep 15 — 1329-32