The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XV.f

Path: Diffuse alveolar damage (DAD-pattern) (see also IL)

Publications

Watkins J, Slade JH, Phan A, Eng C, Weissferdt A, Overman MJ

Fatal diffuse alveolar damage associated with oxaliplatin administration.

Clinical colorectal cancer. 2011;10(3):198-202

Galvão FH, Pestana JO, Capelozzi VL

Fatal gemcitabine-induced pulmonary toxicity in metastatic gallbladder adenocarcinoma.

Cancer chemotherapy and pharmacology. 2010;65(3):607-10

Leo F, Pelosi G, Sonzogni A, Chilosi M, Bonomo G, Spaggiari L

Structural lung damage after chemotherapy fact or fiction?

Lung cancer (Amsterdam, Netherlands). 2010;67(3):306-10

Maniwa K, Tanaka E, Inoue T, Kato T, Sakuramoto M, Minakuchi M, Maeda Y, Noma S, Kobashi Y, Taguchi Y

An autopsy case of acute pulmonary toxicity associated with gemcitabine.

Internal medicine (Tokyo, Japan). 2003;42(10):1022-5

Dai MS, Ho CL, Chen YC, Kao WY, Chao TY

Acute respiratory distress syndrome following intrathecal methotrexate administration: a case report and review of literature.

Annals of hematology. 2000;79(12):696-9

Rossi SE, Erasmus JJ, McAdams HP, Sporn TA, Goodman PC

Pulmonary drug toxicity: radiologic and pathologic manifestations.

Radiographics : a review publication of the Radiological Society of North America, Inc. 2000;20(5):1245-59

Flubacher P, Meier V, Obrecht JP, Hartmann D

[Cytostatic pneumopathy following chemotherapy for metastasizing breast neoplasm].

Schweizerische medizinische Wochenschrift. 1977;107(40):1412-7