The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Methemoglobinemia
Specific to nitric oxide or NO
Publications
Methemoglobinemia in an infant receiving nitric oxide after the use of eutectic mixture of local anesthetic.
The Journal of pediatrics. 2002;141(2):285-6
Inhaled nitric oxide and methemoglobin in full-term infants with persistent pulmonary hypertension of the newborn.
Pulmonary pharmacology & therapeutics. 2002;15(1):1-5
The toxicology of inhaled nitric oxide.
Toxicological sciences : an official journal of the Society of Toxicology. 2001;59(1):5-16