The Drug-Induced Respiratory Disease Website and App

E-cigarette - E-vaporizers - ENDS - Vaping - Dabbing

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.b

Pneumonitis (ILD), acute and/or severe (may cause ARDS)

PMID 34484520

Publications

Roman S, Millet C, Geris S, Manickam R, Mechineni A

Crazy vaping and crazy-paving, a case of E-Cigarette/Vaping-Associated Lung Injury (EVALI) with chest CT showing crazy-paving pattern.

Radiology case reports 2021 Nov;16;3208-3212 — 2021 Nov — 3208-3212

Perrenoud A, Vetos D, Wabwire G

Vaping-induced lung injury in a 21-year-old woman.

BMJ case reports 2020 Nov 30;13; — 2020 Nov 30

Fryman C, Lou B, Weber AG, Steinberg HN, Khanijo S, Iakovou A, Makaryus MR

Acute Respiratory Failure Associated With Vaping.

Chest 2020 Mar;157;e63-e68 — 2020 Mar — e63-e68

Heinzerling A, Armatas C, Karmarkar E, Attfield K, Guo W, Wang Y, Vrdoljak G, Moezzi B, Xu D, Wagner J, Fowles J, Dean C, Cummings KJ, Wilken JA

Severe Lung Injury Associated With Use of e-Cigarette, or Vaping, Products-California, 2019.

JAMA internal medicine 2020 Mar 06;; — 2020 Mar 06

Hartnett KP, Kite-Powell A, Patel MT, Haag BL, Sheppard MJ, Dias TP, King BA, Melstrom PC, Ritchey MD, Stein Z, Idaikkadar N, Vivolo-Kantor AM, Rose DA, Briss PA, Layden JE, Rodgers L, Adjemian J

Syndromic Surveillance for E-Cigarette, or Vaping, Product Use-Associated Lung Injury.

The New England journal of medicine 2020 Feb 20;382 — 2020 Feb 20 — 766-772

Triantafyllou GA, Tiberio PJ, Zou RH, Lamberty PE, Lynch MJ, Kreit JW, Gladwin MT, Morris A, Chiarchiaro J

Vaping-Associated Acute Lung Injury: A Case Series.

American journal of respiratory and critical care medicine 2019 Oct 01;; — 2019 Oct 01

Layden JE, Ghinai I, Pray I, Kimball A, Layer M, Tenforde M, Navon L, Hoots B, Salvatore PP, Elderbrook M, Haupt T, Kanne J, Patel MT, Saathoff-Huber L, King BA, Schier JG, Mikosz CA, Meiman J

Pulmonary Illness Related to E-Cigarette Use in Illinois and Wisconsin - Preliminary Report.

The New England journal of medicine 2019 Sep 06;; — 2019 Sep 06

Sommerfeld CG, Weiner DJ, Nowalk A, Larkin A

Hypersensitivity Pneumonitis and Acute Respiratory Distress Syndrome From E-Cigarette Use.

Pediatrics 2018 06;141; — 2018 06