The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

II.b

ARDS - Acute lung injury

Publications

Montiel V, Huberlant V, Vincent MF, Bonbled F, Hantson P

Multiple organ failure after an overdose of less than 0.4 mg/kg of colchicine: role of coingestants and drugs during intensive care management.

Clinical toxicology (Philadelphia, Pa.). 2010;48(8):845-8

Maurizi M, Delorme N, Laprévote-Heully MC, Lambert H, Larcan A

[Acute respiratory distress syndrome in adults in colchicine poisoning].

Annales francaises d'anesthesie et de reanimation. 1986;5(5):530-2

Hill RN, Spragg RG, Wedel MK, Moser KM

Letter: Adult respiratory distress syndrome associated with colchicine intoxication.

Annals of internal medicine. 1975;83(4):523-4