The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

III.a

Alveolar hemorrhage (AH), diffuse AH (DAH)

Publications

Rejlekova K, Cursano MC, De Giorgi U, Mego M

Severe Complications in Testicular Germ Cell Tumors: The Choriocarcinoma Syndrome.

Frontiers in endocrinology. 2019;10:218

Spira D, Wirths S, Skowronski F, Pintoffl J, Kaufmann S, Brodoefel H, Horger M

Diffuse alveolar hemorrhage in patients with hematological malignancies: HRCT patterns of pulmonary involvement and disease course.

Clinical imaging. 2013;37(4):680-6

Salvucci M, Zanchini R, Molinari A, Zuffa E, Poletti V, Poletti G, Zaccaria A

Lung toxicity following fludarabine, cytosine arabinoside and mitoxantrone (flan) treatment for acute leukemia.

Haematologica. 2000;85(7):769-70

Hoshi S, Itoh A, Kato S, Suzuki K, Kawamura S, Orikasa S

Severe rhabdomyolysis as a complication of high-dose chemotherapy in a patient with advanced testicular cancer.

International journal of urology : official journal of the Japanese Urological Association. 1999;6(1):56-8

Creech RH, Tritchler D, Ettinger DS, Ferraro JA, Ruckdeschel JC, Vogl SE, Woll J

Phase II study of PALA, amsacrine, teniposide, and zinostatin in small cell lung carcinoma (EST 2579).

Cancer treatment reports. 1984;68(9):1183-4

Gordon J

Human B lymphocytes mature.

Clinical and experimental immunology. 1991;84(3):373-5