The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLII.a

Alveolar hemorrhage (AH), diffuse AH (DAH)

Publications

Rejlekova K, Cursano MC, De Giorgi U, Mego M

Severe Complications in Testicular Germ Cell Tumors: The Choriocarcinoma Syndrome.

Frontiers in endocrinology 2019;10;218 — 2019 — 218

Spira D, Wirths S, Skowronski F, Pintoffl J, Kaufmann S, Brodoefel H, Horger M

Diffuse alveolar hemorrhage in patients with hematological malignancies: HRCT patterns of pulmonary involvement and disease course.

Clinical imaging 2013 Jul-Aug;37;680-6 — 2013 Jul-Aug — 680-6

Salvucci M, Zanchini R, Molinari A, Zuffa E, Poletti V, Poletti G, Zaccaria A

Lung toxicity following fludarabine, cytosine arabinoside and mitoxantrone (flan) treatment for acute leukemia.

Haematologica 2000 Jul;85;769-70 — 2000 Jul — 769-70

Hoshi S, Itoh A, Kato S, Suzuki K, Kawamura S, Orikasa S

Severe rhabdomyolysis as a complication of high-dose chemotherapy in a patient with advanced testicular cancer.

International journal of urology : official journal of the Japanese Urological Association 1999 Jan;6;56-8 — 1999 Jan — 56-8

Creech RH, Tritchler D, Ettinger DS, Ferraro JA, Ruckdeschel JC, Vogl SE, Woll J

Phase II study of PALA, amsacrine, teniposide, and zinostatin in small cell lung carcinoma (EST 2579).

Cancer treatment reports 1984 Sep;68;1183-4 — 1984 Sep — 1183-4

Gordon J

Human B lymphocytes mature.

Clinical and experimental immunology 1991 Jun;84;373-5 — 1991 Jun — 373-5