The Drug-Induced Respiratory Disease Website and App

Gases

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

IV.q

Reactive airway dysfunction syndrome (RADS)

Publications

Centers for Disease Control and Prevention (CDC)

Chlorine gas release associated with employee language barrier--Arkansas, 2011.

MMWR. Morbidity and mortality weekly report. 2012;61(48):981-5

Takeda N, Maghni K, Daigle S, L'Archevêque J, Castellanos L, Al-Ramli W, Malo JL, Hamid Q

Long-term pathologic consequences of acute irritant-induced asthma.

The Journal of allergy and clinical immunology. 2009;124(5):975-81.e1