The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.a

Pneumonitis (interstitial lung disease/ILD)

Publications

Méndez-Echevarría A, Fernandez-Prieto A, de la Serna O, Lopez-Gutierrez JC, Parron M, Marin-Aguilera B, Calvo C

Acute Lung Toxicity After Intralesional Bleomycin Sclerotherapy.

Pediatrics 2018 01;141; — 2018 01

Madabhavi I, Modi G, Patel A, Anand A, Panchal H, Parikh S

Pulmonary toxicity following bleomycin use: A single-center experience.

Journal of cancer research and therapeutics 2017 Jul-Sep;13;466-470 — 2017 Jul-Sep — 466-470

Ahmed BM, Al-Zakwani IS

Incidence, outcome and predictors of bleomycin pulmonary toxicity in a university hospital in Oman.

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 2013 Mar;19;3-7 — 2013 Mar — 3-7

Ngeow J, Tan IB, Kanesvaran R, Tan HC, Tao M, Quek R, Lim ST

Prognostic impact of bleomycin-induced pneumonitis on the outcome of Hodgkin's lymphoma.

Annals of hematology 2011 Jan;90;67-72 — 2011 Jan — 67-72

Martin WG, Ristow KM, Habermann TM, Colgan JP, Witzig TE, Ansell SM

Bleomycin pulmonary toxicity has a negative impact on the outcome of patients with Hodgkin's lymphoma.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005 Oct 20;23;7614-20 — 2005 Oct 20 — 7614-20

Bauer KA, Skarin AT, Balikian JP, Garnick MB, Rosenthal DS, Canellos GP

Pulmonary complications associated with combination chemotherapy programs containing bleomycin.

The American journal of medicine 1983 Apr;74;557-63 — 1983 Apr — 557-63

Balikian JP, Jochelson MS, Bauer KA, Skarkin AT, Garnick MB, Canellos GP, Smith EH

Pulmonary complications of chemotherapy regimens containing bleomycin.

AJR. American journal of roentgenology 1982 Sep;139;455-61 — 1982 Sep — 455-61

McLeod BF, Lawrence HJ, Smith DW, Vogt PJ, Gandara DR

Fatal bleomycin toxicity from a low cumulative dose in a patient with renal insufficiency.

Cancer 1987 Dec 01;60;2617-20 — 1987 Dec 01 — 2617-20

Dineen MK, Englander LS, Huben RP

Bleomycin-induced nodular pulmonary fibrosis masquerading as metastatic testicular cancer.

The Journal of urology 1986 Aug;136;473-5 — 1986 Aug — 473-5