The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.g

Pulmonary fibrosis

Publications

Doi M, Okamoto Y, Yamauchi M, Naitou H, Shinozaki K

Bleomycin-induced pulmonary fibrosis after tumor lysis syndrome in a case of advanced yolk sac tumor treated with bleomycin, etoposide and cisplatin (BEP) chemotherapy.

International journal of clinical oncology 2012 Oct;17;528-31 — 2012 Oct — 528-31

Godoy MC, Nonaka D, Raphael BG, Vlahos I

Diffuse ground-glass opacities in a patient with Hodgkin lymphoma and progressive respiratory failure.

Chest 2008 Jul;134;207-12 — 2008 Jul — 207-12

Keijzer A, Kuenen B

Fatal pulmonary toxicity in testis cancer with bleomycin-containing chemotherapy.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007 Aug 10;25;3543-4 — 2007 Aug 10 — 3543-4

Uzel I, Ozguroglu M, Uzel B, Kaynak K, Demirhan O, Akman C, Oz F, Yaman M

Delayed onset bleomycin-induced pneumonitis.

Urology 2005 Jul;66;195 — 2005 Jul — 195

Sleijfer S

Bleomycin-induced pneumonitis.

Chest 2001 Aug;120;617-24 — 2001 Aug — 617-24

Giaccone G, Risio M, Bonardi G, Calciati A

Stevens-Johnson syndrome and fatal pulmonary toxicity to combination chemotherapy containing bleomycin: a case report.

Tumori 1986 Jun 30;72;331-3 — 1986 Jun 30 — 331-3