The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Alveolar hemorrhage (AH), diffuse AH (DAH)
In systemic sclerosis
Publications
Naniwa T, Banno S, Sugiura Y, Yokota K, Oosawa T, Maeda S, Hayami Y, Takahashi N, Ueda R, Matsumoto Y
Pulmonary-renal syndrome in systemic sclerosis: a report of three cases and review of the literature.
Modern rheumatology 2007;17;37-44 — 2007 — 37-44
Normotensive scleroderma renal crisis with diffuse alveolar damage after corticosteroid therapy.
Modern rheumatology 2005;15;134-8 — 2005 — 134-8