The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XIX.d

Path: Organizing pneumonia (OP/BOOP) pattern (see also Id)

Publications

Odish MF, McGuire WC, Thistlethwaite P, Crotty Alexander LE

Bleomycin-induced lung injury treated with venovenous extracorporeal membrane oxygenation (ECMO) and ultra-protective ventilator settings.

BMJ case reports 2020 Nov 23;13; — 2020 Nov 23

Santrach PJ, Askin FB, Wells RJ, Azizkhan RG, Merten DF

Nodular form of bleomycin-related pulmonary injury in patients with osteogenic sarcoma.

Cancer 1989 Aug 15;64;806-11 — 1989 Aug 15 — 806-11

O'Neill TJ, Kardinal CG, Tierney LM

Reversible interstitial pneumonitis associated with low dose bleomycin.

Chest 1975 Aug;68;265-7 — 1975 Aug — 265-7