The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.k

Lung nodule or nodules

Publications

von Rohr L, Klaeser B, Joerger M, Kluckert T, Cerny T, Gillessen S

Increased pulmonary FDG uptake in bleomycin-associated pneumonitis.

Onkologie. 2007;30(6):320-3

Garipidou V, Vakalopoulou S, Zafiriadou E, Kaloutsi V, Tziomalos K, Perifanis V

Uncommon manifestation of bleomycin-induced pulmonary toxicity in a patient with Hodgkin's disease.

Annals of oncology : official journal of the European Society for Medical Oncology. 2005;16(3):514-5

Rossi SE, Erasmus JJ, McAdams HP, Sporn TA, Goodman PC

Pulmonary drug toxicity: radiologic and pathologic manifestations.

Radiographics : a review publication of the Radiological Society of North America, Inc. 2000;20(5):1245-59

Ferrozzi F, Schiavi A, Ganzetti A, Bassi P, Campani R

[Pulmonary iatrogenic lesions in chemotherapy: computerized tomography findings].

La Radiologia medica. 1998;96(1-2):62-7

Ben Arush MW, Roguin A, Zamir E, el-Hassid R, Pries D, Gaitini D, Dale A, Postovsky S

Bleomycin and cyclophosphamide toxicity simulating metastatic nodules to the lungs in childhood cancer.

Pediatric hematology and oncology. 1997;14(4):381-6

Clemm C, Hartenstein R, Mayr B, Wilmanns W

[Bleomycin-induced pulmonary infiltrations in the treatment of testicular cancer].

Klinische Wochenschrift. 1984;62(3):138-44

McCrea ES, Diaconis JN, Wade JC, Johnston CA

Bleomycin toxicity simulating metastatic nodules to the lungs.

Cancer. 1981;48(5):1096-100

Nachman JB, Baum ES, White H, Cruissi FG

Bleomycin-induced pulmonary fibrosis mimicking recurrent metastatic disease in a patient with testicular carcinoma: case report of the CT scan appearance.

Cancer. 1981;47(2):236-9

Cohen MB, Austin JH, Smith-Vaniz A, Lutzky J, Grimes MM

Nodular bleomycin toxicity.

American journal of clinical pathology. 1989;92(1):101-4

Zucker PK, Khouri NF, Rosenshein NB

Bleomycin-induced pulmonary nodules: a variant of bleomycin pulmonary toxicity.

Gynecologic oncology. 1987;28(3):284-91

Talcott JA, Garnick MB, Stomper PC, Godleski JJ, Richie JP

Cavitary lung nodules associated with combination chemotherapy containing bleomycin.

The Journal of urology. 1987;138(3):619-20

Gehl HB, Hauptmann S, Sohn M, Bohndorf K

[Late pulmonary changes following bleomycin administration in computed tomography. Nodular fibrosis mimicking a seminoma metastasis].

Der Radiologe. 1992;32(2):80-2