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The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

II.t

Acute respiratory failure (e.g. from ARDS, ILD, PIE, OP, pulmonary edema or bronchospasm) requiring ECMO

Publications

Hayes D Jr, Board A, Calfee CS, Ellington S, Pollack LA, Kathuria H, Eakin MN, Weissman DN, Callahan SJ, Esper AM, Crotty Alexander LE, Sharma NS, Meyer NJ, Smith LS, Novosad S, Evans ME, Goodman AB, Click ES, Robinson RT, Ewart G, Twentyman E

Pulmonary and Critical Care Considerations for e-Cigarette, or Vaping, Product Use-Associated Lung Injury.

Chest. 2022;162(1):256-264

Villeneuve T, Prevot G, Le Borgne A, Colombat M, Collot S, Ruiz S, Lanot T, Brouchet L, Rabeau A, Noel-Savina E, Didier A

Diffuse alveolar haemorrhage secondary to e-cigarette "vaping" associated lung injury (EVALI) in a young European consumer.

The European respiratory journal. 2020;56(1)

Marlière C, De Greef J, Gohy S, Hoton D, Wallemacq P, Jacquet LM, Belkhir L

Fatal e-cigarette or vaping associated lung injury (EVALI): a first case report in Europe.

The European respiratory journal. 2020;56(1)

Aldy K, Cao DJ, McGetrick M, Willcutts D, Verbeck G, De Silva I, Hsu S

Severe E-Cigarette, or Vaping, Product Use Associated Lung Injury Requiring Venovenous Extracorporeal Membrane Oxygenation.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 2020;21(4):385-388

Baxter RD, Vaquera K, George TJ

Extracorporeal Membrane Oxygenation Support for Vaping-Induced Acute Lung Injury.

The Annals of thoracic surgery. 2020;110(3):e193-e194