The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.c

Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

Publications

Hapani S, Chu D, Wu S

Eosinophilic pneumonia associated with bleomycin in a patient with mediastinal seminoma: a case report.

Journal of medical case reports. 2010;4:126

Santrach PJ, Askin FB, Wells RJ, Azizkhan RG, Merten DF

Nodular form of bleomycin-related pulmonary injury in patients with osteogenic sarcoma.

Cancer. 1989;64(4):806-11

Yousem SA, Lifson JD, Colby TV

Chemotherapy-induced eosinophilic pneumonia. Relation to bleomycin.

Chest. 1985;88(1):103-6

Holoye PY, Luna MA, MacKay B, Bedrossian CW

Bleomycin hypersensitivity pneumonitis.

Annals of internal medicine. 1978;88(1):47-9