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The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

VI.r

Septic pulmonary embolism

The main signs and symptoms include fever, dyspnea, chest pain, and cough. Imaging features include multiple bilateral peripheral nodules, cavitation, focal or wedge-shaped infiltrates and pleural effusion. Echocardiography may reveal vegetations. Blood cultures can grow Staphylococcus aureus or Candida (PMID 24183289)

Publications

Gupta S, Banach DB, Chirch LM

Pulmonary artery intravascular abscess: A rare complication of incomplete infective endocarditis treatment in the setting of injection drug use.

IDCases. 2018;12:88-91

Wakeman SE, Ghoshhajra BB, Dudzinski DM, Wilens T, Slavin PL

Case records of the Massachusetts General Hospital. Case 35-2014: a 31-year-old woman with fevers, chest pain, and a history of HCV infection and substance-use disorder.

The New England journal of medicine. 2014;371(20):1918-26

Ye R, Zhao L, Wang C, Wu X, Yan H

Clinical characteristics of septic pulmonary embolism in adults: a systematic review.

Respiratory medicine. 2014;108(1):1-8

Pena E, Dennie C, Franquet T, Milroy C

Nonthrombotic pulmonary embolism: a radiological perspective.

Seminars in ultrasound, CT, and MR. 2012;33(6):522-34

Yasar KK, Pehlivanoglu F, Gursoy S, Sengoz G

Tricuspid Endocarditis and Septic Pulmonary Embolism in an Intravenous Drug User with advanced HIV Infection.

Oman medical journal. 2011;26(5):365-7

Brunetti ND, De Gennaro L, Basile DP, De Cillis E, Acquaviva T, Boscia F, Di Biase M, Bortone AS

A "strange cough": 3D-echocardiography for diagnosis of late tricuspid valve endocarditis in a former drug addict with septic pulmonary emboli.

International journal of cardiology. 2011;153(1):e15-8

Saydain G, Singh J, Dalal B, Yoo W, Levine DP

Outcome of patients with injection drug use-associated endocarditis admitted to an intensive care unit.

Journal of critical care. 2010;25(2):248-53

Dawson DJ, Peters L

"Street" supplies of the anticoagulant drug warfarin: a worrying new trend.

Emergency medicine journal : EMJ. 2006;23(6):488-9

Fäh F, Zimmerli W, Jordi M, Schoenenberger RA

Septic deep venous thrombosis in intravenous drug users.

Swiss medical weekly. 2002;132(27-28):386-92

Aguado JM, Arjona R, Ugarte P

Septic pulmonary emboli. A rare cause of bilateral pneumothorax in drug abusers.

Chest. 1990;98(5):1302-4