The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Septic pulmonary embolism
The main signs and symptoms include fever, dyspnea, chest pain, and cough. Imaging features include multiple bilateral peripheral nodules, cavitation, focal or wedge-shaped infiltrates and pleural effusion. Echocardiography may reveal vegetations. Blood cultures can grow Staphylococcus aureus or Candida (PMID 24183289)
Publications
Pulmonary artery intravascular abscess: A rare complication of incomplete infective endocarditis treatment in the setting of injection drug use.
IDCases 2018;12;88-91 — 2018 — 88-91
Case records of the Massachusetts General Hospital. Case 35-2014: a 31-year-old woman with fevers, chest pain, and a history of HCV infection and substance-use disorder.
The New England journal of medicine 2014 Nov 13;371;1918-26 — 2014 Nov 13 — 1918-26
Clinical characteristics of septic pulmonary embolism in adults: a systematic review.
Respiratory medicine 2014 Jan;108;1-8 — 2014 Jan — 1-8
Nonthrombotic pulmonary embolism: a radiological perspective.
Seminars in ultrasound, CT, and MR 2012 Dec;33;522-34 — 2012 Dec — 522-34
Tricuspid Endocarditis and Septic Pulmonary Embolism in an Intravenous Drug User with advanced HIV Infection.
Oman medical journal 2011 Sep;26;365-7 — 2011 Sep — 365-7
A "strange cough": 3D-echocardiography for diagnosis of late tricuspid valve endocarditis in a former drug addict with septic pulmonary emboli.
International journal of cardiology 2011 Nov 17;153;e15-8 — 2011 Nov 17 — e15-8
Outcome of patients with injection drug use-associated endocarditis admitted to an intensive care unit.
Journal of critical care 2010 Jun;25;248-53 — 2010 Jun — 248-53
"Street" supplies of the anticoagulant drug warfarin: a worrying new trend.
Emergency medicine journal : EMJ 2006 Jun;23;488-9 — 2006 Jun — 488-9
Septic deep venous thrombosis in intravenous drug users.
Swiss medical weekly 2002 Jul 13;132;386-92 — 2002 Jul 13 — 386-92
Septic pulmonary emboli. A rare cause of bilateral pneumothorax in drug abusers.
Chest 1990 Nov;98;1302-4 — 1990 Nov — 1302-4