The Drug-Induced Respiratory Disease Website and App

XII.c

XII - Cardiovascular involvement / toxicity

Pericardial effusion (w/wo tamponade)

Last update 17/06/2026

Pericarditis (i.e. pericardial inflammation) is usually heralded by acute mediothoracic chest pain (PMID 10878205). Large effusions can be ANA positive and cause pericardial tamponade. When present as a longterm sequela, pericardial thickening may cause restriction and constriction. See also under Vc, d, g, m and XIIk (PMID 20511488, 23376916)

Causative drugs

58

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.a
I.b
I.c
I.d
I.e
I.f
I.g
I.h
I.k
I.l
I.s
I.u
I.w
I.z
I.aa
I.ao
I.at
I.ax
I.ay
II.b
II.l
III.a
III.c
IV.a
IV.d
IV.r
V.a
V.c
V.d
V.t
VI.a
VI.i
VIII.a
IX.a
IX.d
IX.ai
X.d
X.f
X.q
XI.c
XI.f
XII.a
XII.c
XII.e
XII.l
XII.n
XII.p
XII.t
XII.af
XII.au
XV.a
XV.b
XV.c
XV.d
XV.f
XV.g
XV.h
XV.i
XV.j
XV.k
XV.m
XV.o
XV.r
XV.ao
XV.bt
XV.co
XV.dc
XVI.b
XVI.i
XVI.j
XVI.n
XVI.s
XVI.w
XVI.aa
XVI.ab
XVI.ay
XVI.az
XVI.bj
XVI.bq
XVI.bt
XVI.bx
XVI.ca
XVII.e
XVIII.b
XVIII.j
XVIII.k
XVIII.p
XIX.a
XIX.b
XIX.c
XIX.e
XIX.f
XIX.m
XIX.p
XXVIII.c
I.j
I.n
II.b
II.d
II.f
III.a
IV.x
VI.e
X.u
XII.a
XII.c
XII.f
XII.g
XII.l
XII.o
XII.v
XII.ai
XV.n
XV.p
XV.bu
I.b
I.c
I.n
I.al
I.am
II.t
III.a
V.a
V.v
V.w
VII.a
VII.e
VII.p
X.e
X.h
X.j
X.k
X.m
X.q
X.s
X.ad
XII.c
XIII.f
XIII.h
XIII.i
XV.m
XV.bn
XV.cq
XV.cr
XVI.k
XVI.av
XVI.bh
XVIII.c
I.ao
II.a
II.b
II.q
II.v
III.c
V.a
VI.a
X.an
XII.a
XII.c
XII.f
XII.l
XII.m
XII.n
XII.p
XII.r
XII.af
XII.ah
XII.ai
XII.ba
XII.bs
XII.cc
XVII.b
I.a
I.b
I.c
I.d
I.e
I.k
I.l
II.a
II.b
IV.a
V.a
V.d
VII.a
VII.b
X.a
X.d
X.m
XII.a
XII.c
XII.d
XII.l
XII.s
XIII.b
XV.a
XV.b
XV.c
XV.e
XVI.ab
I.a
I.b
I.g
I.l
I.x
I.ad
II.a
II.b
V.a
V.f
V.m
V.ab
XII.c
XV.a
XV.f
XV.h
XV.i
XV.ap
XVI.a
XVI.b
XVI.m
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