The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.a

Pneumonitis (ILD), acute and/or severe (may produce the ARDS pattern)

Publications

Sharma S, Patti R, Soni P, Ehrlich S, Kupfer Y

Amiodarone toxicity and the acute respiratory distress syndrome.

QJM : monthly journal of the Association of Physicians. 2019;112(11):880-881

Baumann H, Fichtenkamm P, Schneider T, Biscoping J, Henrich M

Rapid onset of amiodarone induced pulmonary toxicity after lung lobe resection - A case report and review of recent literature.

Annals of medicine and surgery (2012). 2017;21:53-57

Yoon U, Marinelli L, Ali S, Huberfeld S, Barrera R, Chang JB

Early Amiodarone-Induced Pulmonary Toxicity after Endovascular Aneurysm Repair: A Case Report.

The International journal of angiology : official publication of the International College of Angiology, Inc. 2016;25(3):189-92

Kumar S, Bangalore S, Kumari R, Grosu H, Jean R

Amiodarone-induced acute respiratory distress syndrome masquerading as acute heart failure.

The Journal of emergency medicine. 2012;43(5):e311-4

Lehmann LH, Weichert W, Schnapauff D, Dietz R, Stockburger M

Interstitial pneumonitis with accumulation of intraalveolar macrophages, a facet amiodarone therapy.

Clinical research in cardiology : official journal of the German Cardiac Society. 2008;97(12):917-20

Rotmensch HH, Liron M, Tupilski M, Laniado S

Possible association of pneumonitis with amiodarone therapy.

American heart journal. 1980;100(3):412-3