The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.c

Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

Publications

Anai S, Nakayama Y, Gushiken H, Chinen S, Masuda K, Kamiya H, Ueno S, Maeda M, Kiyuna M, Sato Y, Matsumoto T

Diffuse alveolar hemorrhage and acute eosinophilic pneumonia: A rare form of amiodarone pulmonary toxicity diagnosed by bronchoalveolar lavage.

Journal of cardiology cases 2023 Mar;27;93-96 — 2023 Mar — 93-96

Azraai M, McMahon M, Dick R

Case report of amiodarone-associated allergic pneumonitis amidst the COVID-19 pandemic.

Reviews in cardiovascular medicine 2021 03 30;22;181-184 — 2021 03 30 — 181-184

LeVee A, Trieu M, Bhattacharyya S, Sandhu G

Eosinophilic pneumonia: A rare manifestation of amiodarone toxicity diagnosed using traditional bronchoscopy.

Respiratory medicine case reports 2019;27;100856 — 2019 — 100856

Larsen BT, Vaszar LT, Colby TV, Tazelaar HD

Lymphoid hyperplasia and eosinophilic pneumonia as histologic manifestations of amiodarone-induced lung toxicity.

The American journal of surgical pathology 2012 Apr;36;509-16 — 2012 Apr — 509-16