The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLV.f

Pneumothorax

Publications

Wilson KS, Brigden ML, Alexander S, Worth A

Fatal pneumothorax in "BCNU lung".

Medical and pediatric oncology 1982;10;195-9 — 1982 — 195-9

O'Driscoll BR, Hasleton PS, Taylor PM, Poulter LW, Gattameneni HR, Woodcock AA

Active lung fibrosis up to 17 years after chemotherapy with carmustine (BCNU) in childhood.

The New England journal of medicine 1990 Aug 09;323;378-82 — 1990 Aug 09 — 378-82