The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.m

Diffuse alveolar damage (DAD) (see alsoo under IIb and XVf)

Publications

Nacca N, Bhamidipati CM, Yuhico LS, Pinnamaneni S, Szombathy T

Severe amiodarone induced pulmonary toxicity.

Journal of thoracic disease 2012 Dec;4;667-70 — 2012 Dec — 667-70

Argyriou M, Hountis P, Antonopoulos N, Mathioudaki M

Acute fatal post-CABG low dose amiodarone lung toxicity.

Asian cardiovascular & thoracic annals 2007 Dec;15;e66-8 — 2007 Dec — e66-8

Parambil JG, Myers JL, Aubry MC, Ryu JH

Causes and prognosis of diffuse alveolar damage diagnosed on surgical lung biopsy.

Chest 2007 Jul;132;50-7 — 2007 Jul — 50-7