The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Sarcoid-like granulomatosis (endo-/extrathoracic)
Publications
Siliconosis: autoimmune/inflammatory syndrome induced by adjuvants (ASIA).
The Israel Medical Association journal : IMAJ. 2012;14(2):137-8
Cutaneous and pulmonary sarcoidosis in a Hong Kong Chinese woman with silicone breast prostheses.
Respirology (Carlton, Vic.). 2003;8(3):379-82
Remission of sarcoidosis following removal of silicone gel breast implants.
International archives of allergy and immunology. 1994;105(4):404-7