Back
The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
I - Interstitial/parenchymal lung disease
XLI - Pulmonary edema - Acute lung injury - ARDS
XLII - Pulmonary/alveolar./airway hemorrhage/bleeding
XLV - Pleural and/or pericardial involvement
XLVI - Pulmonary vasculopathy
XLIX - Systemic/Distant conditions, syndromes and reactions
LI - Cardiovascular involvement / toxicity
LI.a
Left or biventricular dysfunction/failure
LI.c
Pericardial effusion (w/wo tamponade)
LI.g
Cardiomyopathy (acute, subacute, chronic)
LI.n
Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)
LI.o
Cardiovascular collapse - Cardiogenic shock - Hypotension
LI.q
QTc prolongation
LI.s
Heart failure (biventricular, congestive)
LI.u
Cardiac- cardiorespiratory/pulmonary arrest
LI.ah
Coronary vasospasm - Vasospastic angina
LI.aj
Tachycardia
LI.ak
Cardiotoxicity
LI.bd
Sudden cardiac death
LI.bv
ST segment elevation
LI.bw
ST segment changes