The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLIII.a

Bronchospasm - Wheezing - Asthma

Publications

Yavuzgil O, Goksel T, Gurgun C, Hasdemir C

New-onset bronchial asthma induced by low-dose amiodarone.

The Annals of pharmacotherapy 2005 Feb;39;385-6 — 2005 Feb — 385-6

Imamura H, Kinoshita O, Maruyama K, Izawa A, Uchikawa SI, Kumazaki S, Takahashi W, Yokoseki O, Yazaki Y, Koizumi T, Kubo K

Two cases of bronchial asthma after treatment with amiodarone.

Pacing and clinical electrophysiology : PACE 2001 Oct;24;1563-5 — 2001 Oct — 1563-5

Hunt D, Kertes P, Venables S, Callaghan J, Harrison LC

Exacerbation of bronchial asthma following treatment with amiodarone. Demonstration of an antiadrenergic effect in vitro.

Chest 1984 Sep;86;492-4 — 1984 Sep — 492-4