The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

II.b

ARDS - Acute lung injury

Due to severity of the illness, ECMO had to be used in some cases (PMID 24604330)

Publications

Sharma S, Patti R, Soni P, Ehrlich S, Kupfer Y

Amiodarone toxicity and the acute respiratory distress syndrome.

QJM : monthly journal of the Association of Physicians. 2019;112(11):880-881

Gerard L, Bidoul T, Castanares-Zapatero D, Wittebole X, Lacroix V, Froidure A, Hoton D, Laterre PF

Open Lung Biopsy in Nonresolving Acute Respiratory Distress Syndrome Commonly Identifies Corticosteroid-Sensitive Pathologies, Associated With Better Outcome.

Critical care medicine. 2018;46(6):907-914

Gibelin A, Parrot A, Maitre B, Brun-Buisson C, Mekontso Dessap A, Fartoukh M, de Prost N

Acute respiratory distress syndrome mimickers lacking common risk factors of the Berlin definition.

Intensive care medicine. 2016;42(2):164-72

Benassi F, Molardi A, Righi E, Santangelo R, Meli M

ECMO for pulmonary rescue in an adult with amiodarone-induced toxicity.

Heart and vessels. 2015;30(3):410-5

Sato N, Kojima K, Horio Y, Goto E, Masunaga A, Ichiyasu H, Kohrogi H

Successful treatment of severe amiodarone pulmonary toxicity with polymyxin B-immobilized fiber column direct hemoperfusion.

Chest. 2013;143(4):1146-1150

Range FT, Hilker E, Breithardt G, Buerke B, Lebiedz P

Amiodarone-induced pulmonary toxicity--a fatal case report and literature review.

Cardiovascular drugs and therapy. 2013;27(3):247-54

Dhokarh R, Li G, Schmickl CN, Kashyap R, Assudani J, Limper AH, Gajic O

Drug-associated acute lung injury: a population-based cohort study.

Chest. 2012;142(4):845-850

Karnatovskaia LV, Festic E, Gajic O, Carter RE, Lee AS, US Critical Illness and Injury Trials Group: Lung Injury Prevention Study Investigators (USCIITG-LIPS)

Prehospital amiodarone may increase the incidence of acute respiratory distress syndrome among patients at risk.

Journal of critical care. 2012;27(5):447-53

Jackevicius CA, Tom A, Essebag V, Eisenberg MJ, Rahme E, Tu JV, Humphries K, Behlouli H, Pilote L

Population-level incidence and risk factors for pulmonary toxicity associated with amiodarone.

The American journal of cardiology. 2011;108(5):705-10

Kumar S, Bangalore S, Kumari R, Grosu H, Jean R

Amiodarone-induced acute respiratory distress syndrome masquerading as acute heart failure.

The Journal of emergency medicine. 2012;43(5):e311-4

Argyriou M, Hountis P, Antonopoulos N, Mathioudaki M

Acute fatal post-CABG low dose amiodarone lung toxicity.

Asian cardiovascular & thoracic annals. 2007;15(6):e66-8

Skroubis G, Galiatsou E, Metafratzi Z, Karahaliou A, Kitsakos A, Nakos G

Amiodarone-induced acute lung toxicity in an ICU setting.

Acta anaesthesiologica Scandinavica. 2005;49(4):569-71

Ashrafian H, Davey P

Is amiodarone an underrecognized cause of acute respiratory failure in the ICU?

Chest. 2001;120(1):275-82

Donaldson L, Grant IS, Naysmith MR, Thomas JS

Acute amiodarone-induced lung toxicity.

Intensive care medicine. 1998;24(6):626-30

Donaldson L, Grant IS, Naysmith MR, Thomas JS

Amiodarone pulmonary toxicity. Amiodarone should be used with caution in patients in intensive care.

BMJ (Clinical research ed.). 1997;314(7097):1832

Kay GN, Epstein AE, Kirklin JK, Diethelm AG, Graybar G, Plumb VJ

Fatal postoperative amiodarone pulmonary toxicity.

The American journal of cardiology. 1988;62(7):490-2

Greenspon AJ, Kidwell GA, Hurley W, Mannion J

Amiodarone-related postoperative adult respiratory distress syndrome.

Circulation. 1991;84(5 Suppl):III407-15