The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
ARDS - Acute lung injury
Publications
Adult respiratory distress syndrome associated with amitriptyline overdose.
Veterinary and human toxicology. 1994;36(4):316-7
Pulmonary disease after amitriptyline overdosage.
British medical journal. 1973;2(5861):300-1
Pulmonary disease after amitriptyline overdosage.
British medical journal. 1973;1(5855):716-7
[Acute adult respiratory distress syndrome (ARDS) in a patient with amitriptyline poisoning].
Ugeskrift for laeger. 1991;153(11):793-4