The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

II.b

ARDS - Acute lung injury

Publications

Cardinale L, Asteggiano F, Moretti F, Torre F, Ulisciani S, Fava C, Rege-Cambrin G

Pathophysiology, clinical features and radiological findings of differentiation syndrome/all-trans-retinoic acid syndrome.

World journal of radiology. 2014;6(8):583-8

Rego EM, De Santis GC

Differentiation syndrome in promyelocytic leukemia: clinical presentation, pathogenesis and treatment.

Mediterranean journal of hematology and infectious diseases. 2011;3(1):e2011048

Ahmed Z, Shaikh MA, Raval A, Mehta JB, Byrd RP Jr, Roy TM

All-trans retinoic acid syndrome: another cause of drug-induced respiratory failure.

Southern medical journal. 2007;100(9):899-902

Koenig SM

Drug-induced respiratory disease: "the great mimicker".

Southern medical journal. 2007;100(9):863-4

Jung JI, Choi JE, Hahn ST, Min CK, Kim CC, Park SH

Radiologic features of all-trans-retinoic acid syndrome.

AJR. American journal of roentgenology. 2002;178(2):475-80

Amano Y, Tajika K, Mizuki T, Amano M, Dan K, Kumazaki T

All-trans retinoic acid syndrome: chest CT assessment.

European radiology. 2001;11(8):1516-7

Lester WA, Hull DR, Fegan CD, Morris TC

Respiratory failure during induction chemotherapy for acute myelomonocytic leukaemia (FAB M4Eo) with ara-C and all-trans retinoic acid.

British journal of haematology. 2000;109(4):847-50

Tallman MS, Andersen JW, Schiffer CA, Appelbaum FR, Feusner JH, Ogden A, Shepherd L, Rowe JM, François C, Larson RS, Wiernik PH

Clinical description of 44 patients with acute promyelocytic leukemia who developed the retinoic acid syndrome.

Blood. 2000;95(1):90-5

De Botton S, Dombret H, Sanz M, Miguel JS, Caillot D, Zittoun R, Gardembas M, Stamatoulas A, Condé E, Guerci A, Gardin C, Geiser K, Makhoul DC, Reman O, de la Serna J, Lefrere F, Chomienne C, Chastang C, Degos L, Fenaux P

Incidence, clinical features, and outcome of all trans-retinoic acid syndrome in 413 cases of newly diagnosed acute promyelocytic leukemia. The European APL Group.

Blood. 1998;92(8):2712-8