The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

X.ab

The differentiation- or ATRA syndrome

Includes fever, weight gain, peripheral edema, respiratory distress, interstitial pulmonary opacities, pleural and/or pericardial effusions, hypotension and renal failure. See also under IIb (ARDS) and Va

Publications

Weir DC, Fung JY, Braman SS

A 56-year-old man with acute promyelocytic leukemia and pulmonary infiltrates.

Chest. 2014;146(3):e88-e91

Cardinale L, Asteggiano F, Moretti F, Torre F, Ulisciani S, Fava C, Rege-Cambrin G

Pathophysiology, clinical features and radiological findings of differentiation syndrome/all-trans-retinoic acid syndrome.

World journal of radiology. 2014;6(8):583-8

Tariq Z, Phinney RC, Mohamed I

A case of life-threatening retinoic acid syndrome and review of literature.

American journal of therapeutics. 2014;21(2):e28-30

Patatanian E, Thompson DF

Retinoic acid syndrome: a review.

Journal of clinical pharmacy and therapeutics. 2008;33(4):331-8

Koenig SM

Drug-induced respiratory disease: "the great mimicker".

Southern medical journal. 2007;100(9):863-4

La Fianza A, Bonfichi M, Gorone MS, Gallotti A, Torretta L

Unusual abdominal findings of all-trans-retinoic acid syndrome: role of diagnostic imaging.

Clinical imaging. 2007;31(4):276-8

Larson RS, Tallman MS

Retinoic acid syndrome: manifestations, pathogenesis, and treatment.

Best practice & research. Clinical haematology. 2003;16(3):453-61

Jung JI, Choi JE, Hahn ST, Min CK, Kim CC, Park SH

Radiologic features of all-trans-retinoic acid syndrome.

AJR. American journal of roentgenology. 2002;178(2):475-80

De Botton S, Dombret H, Sanz M, Miguel JS, Caillot D, Zittoun R, Gardembas M, Stamatoulas A, Condé E, Guerci A, Gardin C, Geiser K, Makhoul DC, Reman O, de la Serna J, Lefrere F, Chomienne C, Chastang C, Degos L, Fenaux P

Incidence, clinical features, and outcome of all trans-retinoic acid syndrome in 413 cases of newly diagnosed acute promyelocytic leukemia. The European APL Group.

Blood. 1998;92(8):2712-8