The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XVIII.k

Eye-catcher: An electron-dense liver on unenhanced CT

Publications

Carvalho JG, Fernandes C, França M

Organizing pneumonia secondary to amiodarone treatment.

Heliyon. 2022;8(9):e10630

You HS, Yoon JH, Cho SB, Choi YD, Kim YH, Choi W, Kang HC, Choi SK

Amiodarone-Induced Multi-Systemic Toxicity Involving the Liver, Lungs, Thyroid, and Eyes: A Case Report.

Frontiers in cardiovascular medicine. 2022;9:839441

Matsuura H, Kiura Y, Shimizu W, Suganami Y, Sasaki E, Kawamura K, Suganami Y, Kishida M

Amiodarone-induced pneumonitis.

QJM : monthly journal of the Association of Physicians. 2021;114(6):426-427

Lv HJ, Zhao HW

Amiodarone-induced hepatotoxicity - quantitative measurement of iodine density in the liver using dual-energy computed tomography: Three case reports.

World journal of clinical cases. 2020;8(20):4958-4965

Keng LT, Liao MT

Amiodarone-induced hepatic and pulmonary toxicity.

Postgraduate medical journal. 2018;94(1116):603

Matsuda M, Otaka A, Tozawa T, Asano T, Ishiyama K, Hashimoto M

Analysis of computed tomography density of liver before and after amiodarone administration.

Japanese journal of radiology. 2018;36(5):340-344

Pecnik P, Ranftl V, Windpessl M

High liver density on CT imaging due to amiodarone toxicity.

Wiener klinische Wochenschrift. 2018;130(5-6):220-221

Kenzaka T

Hepatic computed tomography changes caused by amiodarone.

The Korean journal of internal medicine. 2015;30(5):745-6

Kim BB, Kim DM, Choi DH, Chung JW, Koh YY, Chang KS, Hong SP

Amiodarone toxicity showing high liver density on CT scan with normal liver function and plasma amiodarone levels in a long-term amiodarone user.

International journal of cardiology. 2014;172(2):494-5

Hochhegger B, Soares Souza A Jr, Zanetti G, Marchiori E

An enlarged heart with hyperdense consolidation.

The Netherlands journal of medicine. 2013;71(6):317, 321

Jones WP, Shin MS, Stanley RJ, Duncan-Myers J

Dense liver in a 72-year-old woman with congestive heart failure.

Investigative radiology. 1985;20(9):911-5

Goldman IS, Winkler ML, Raper SE, Barker ME, Keung E, Goldberg HI, Boyer TD

Increased hepatic density and phospholipidosis due to amiodarone.

AJR. American journal of roentgenology. 1985;144(3):541-6